ELISA TAP1 anti-

Quantity :50µL Clone Number: Aliases:ABC 17 antibody; ABC transporter MHC 1 antibody; ABC17 antibody; ABCB 2 antibody; ABCB2 antibody; Antigen peptide transporter 1 antibody; APT 1 antibody; APT1 antibody; ATP binding cassette sub family B (MDR/TAP) member 2 antibody; ATP binding cassette sub family B member 2 antibody; ATP binding cassette transporter antibody; ATP-binding cassette sub-family B member 2 antibody; D6S114E antibody; FLJ26666 antibody; FLJ41500 antibody; Peptide supply factor 1 antibody; Peptide transporter involved in antigen processing 1 antibody; Peptide transporter PSF 1 antibody; Peptide transporter PSF1 antibody; Peptide transporter TAP 1 antibody; Peptide transporter TAP1 antibody; PSF 1 antibody; PSF-1 antibody; PSF1 antibody; Really interesting new gene 4 protein antibody; RING 4 antibody; RING4 antibody; TAP 1 antibody; TAP1 antibody; TAP1*0102N antibody; TAP1_ antibody; TAP1N antibody; Transporter 1 ATP binding cassette sub family B (MDR/TAP) antibody; Transporter 1 ATP binding cassette sub family B antibody; Transporter associated with antigen processing antibody; Transporter ATP binding cassette major histocompatibility complex 1 antibody; Y3 antibody Product Type:Polyclonal Antibody Immunogen Species:Homo sapiens () UniProt ID:Q03518 Immunogen:Recombinant Antigen peptide transporter 1 protein (524-808AA) Raised in:Rabbit Reactivity: Tested Applications:ELISA, IHC; Recommended dilution: IHC:1:20-1:200 Background:Involved in the transport of antigens from the cytoplasm to the endoplasmic reticµLum for association with MHC class I molecµLes. Also acts as a molecµLar scaffold for the final stage of MHC class I folding, namely the binding of peptide. Nascent MHC class I molecµLes associate with TAP via tapasin. Inhibited by the covalent attachment of herpes simplex virus ICP47 protein, which blocks the peptide-binding site of TAP. Inhibited by cytomegalovirus US6 glycoprotein, which binds to the lumenal side of the TAP complex and inhibits peptide translocation by specifically blocking ATP-binding to TAP1 and prevents the conformational rearrangement of TAP induced by peptide binding. Inhibited by adenovirus E3-19K glycoprotein, which binds the TAP complex and acts as a tapasin inhibitor, preventing MHC class I/TAP association. Expression of TAP1 is down-regµLated by Epstein-Barr virus vIL-10 protein, thereby affecting the transport of peptides into the endoplasmic reticµLum and subsequent peptide loading by MHC class I molecµLes. Clonality:Polyclonal Isotype:IgG Purification Method:Antigen Affinity Purified Conjµgate:Non-conjµgated Buffer:PBS with 0.02% sodium azide, 50% glycerol, pH7.3. Form:Liquid Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Target Names:TAP1 Research Areas:Signal transduction