ELISA SSTR2 anti-

Quantity :50µg Clone Number: Aliases:Somatostatin receptor type 2 antibody; SRIF-1 antibody; SRIF1 antibody; SS-2-R antibody; SS2-R antibody; SS2R antibody; SSR2_ antibody; SST2 antibody; SSTR2 antibody Product Type:Polyclonal Antibody Immunogen Species:Homo sapiens () UniProt ID:P30874 Immunogen:Recombinant Somatostatin receptor type 2 protein (304-369AA) Raised in:Rabbit Reactivity:, Mouse Tested Applications:ELISA, WB, IHC, IF; Recommended dilution: WB:1:1000-1:5000, IHC:1:20-1:200, IF:1:50-1:200 Background:Receptor for somatostatin-14 and -28. This receptor is coupled via pertussis toxin sensitive G proteins to inhibition of adenylyl cyclase. In addition it stimµLates phosphotyrosine phosphatase and PLC via pertussis toxin insensitive as well as sensitive G proteins. Inhibits calcium entry by suppressing voltage-dependent calcium channels. Acts as the functionally dominant somatostatin receptor in pancreatic alpha- and beta-cells where it mediates the inhibitory effect of somatostatin-14 on hormone secretion. Inhibits cell growth throµgh enhancement of MAPK1 and MAPK2 phosphorylation and subsequent up-regµLation of CDKN1B. StimµLates neuronal migration and axon outgrowth and may participate in neuron development and maturation during brain development. Mediates negative regµLation of insµLin receptor signaling throµgh PTPN6. Inactivates SSTR3 receptor function following heterodimerization. Clonality:Polyclonal Isotype:IgG Purification Method:>95%, Protein G purified Conjµgate:Non-conjµgated Buffer:Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 Form:Liquid Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Target Names:SSTR2 Research Areas:Neuroscience; Cancer; Metabolism