ELISA SPOP Antibody, HRP

Quantity :50µg Clone Number: Aliases:BTBD32 antibody; HIB homolog 1 antibody; Roadkill homolog 1 antibody; Speckle type POZ protein antibody; Speckle-type POZ protein antibody; SPOP antibody; SPOP_ antibody; TEF 2 antibody; TEF2 antibody Product Type:Polyclonal Antibody Immunogen Species:Homo sapiens () UniProt ID:O43791 Immunogen:Recombinant Speckle-type POZ protein (48-374AA) Raised in:Rabbit Reactivity: Tested Applications:ELISA Background:Component of a cµLlin-RING-based BCR (BTB-CµL3-RBX1) E3 ubiquitin-protein ligase complex that mediates the ubiquitination of target proteins, leading most often to their proteasomal degradation. In complex with CµL3, involved in ubiquitination and proteasomal degradation of BRMS1, DAXX, PDX1/IPF1, GLI2 and GLI3. In complex with CµL3, involved in ubiquitination of H2AFY and BMI1; this does not lead to their proteasomal degradation. Inhibits transcriptional activation of PDX1/IPF1 targets, such as insµLin, by promoting PDX1/IPF1 degradation. The cµLlin-RING-based BCR (BTB-CµL3-RBX1) E3 ubiquitin-protein ligase complex containing homodimeric SPOP has higher ubiquitin ligase activity than the complex that contains the heterodimer formed by SPOP and SPOPL. Clonality:Polyclonal Isotype:IgG Purification Method:>95%, Protein G purified Conjµgate:HRP Buffer:Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 Form:Liquid Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Target Names:SPOP Research Areas:Epigenetics and Nuclear Signaling