ELISA SOCS5 anti-

Quantity :50µL Clone Number: Aliases:SOCS5 antibody; CIS6 antibody; CISH5 antibody; CISH6 antibody; KIAA0671Suppressor of cytokine signaling 5 antibody; SOCS-5 antibody; Cytokine-inducible SH2 protein 6 antibody; CIS-6 antibody; Cytokine-inducible SH2-containing protein 5 antibody Product Type:Polyclonal Antibody Immunogen Species:Homo sapiens () UniProt ID:O75159 Immunogen:Recombinant Suppressor of cytokine signaling 5 protein (1-270AA) Raised in:Rabbit Reactivity: Tested Applications:ELISA, WB, IHC; Recommended dilution: WB:1:1000-1:5000, IHC:1:20-1:200 Background:SOCS family proteins form part of a classical negative feedback system that regµLates cytokine signal transduction. May be a substrate-recognition component of a SCF-like ECS (Elongin BC-CµL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Inhibits for instance EGF signaling by mediating the degradation of the EGF receptor/EGFR. Involved in the regµLation of T-helper cell differentiation by inhibiting of the IL4 signaling pathway which promotes differentiation into the Th2 phenotype. Can also partially inhibit IL6 and LIF signaling. Clonality:Polyclonal Isotype:IgG Purification Method:Antigen Affinity Purified Conjµgate:Non-conjµgated Buffer:PBS with 0.02% sodium azide, 50% glycerol, pH7.3. Form:Liquid Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Target Names:SOCS5 Research Areas:Immunology; Signal transduction