ELISA SLC22A1 Antibody, Biotin

Quantity :50µg Clone Number: Aliases:hOCT1 antibody; OCT1 antibody; oct1_cds antibody; Organic cation transporter 1 antibody; S22A1_ antibody; Slc22a1 antibody; solute carrier family 22 (organic cation transporter), member 1 antibody; Solute carrier family 22 member 1 antibody Product Type:Polyclonal Antibody Immunogen Species:Homo sapiens () UniProt ID:O15245 Immunogen:Recombinant Solute carrier family 22 member 1 protein (43-149AA) Raised in:Rabbit Reactivity: Tested Applications:ELISA Background:Translocates a broad array of organic cations with various structures and molecµLar weights including the model compounds 1-methyl-4-phenylpyridinium (MPP), tetraethylammonium (TEA), N-1-methylnicotinamide (NMN), 4-(4-(dimethylamino)styryl)-N-methylpyridinium (ASP), the endogenous compounds choline, guanidine, histamine, epinephrine, adrenaline, noradrenaline and dopamine, and the drµgs quinine, and metformin. The transport of organic cations is inhibited by a broad array of compounds like tetramethylammonium (TMA), cocaine, lidocaine, NMDA receptor antagonists, atropine, prazosin, cimetidine, TEA and NMN, guanidine, cimetidine, choline, procainamide, quinine, tetrabutylammonium, and tetrapentylammonium. Translocates organic cations in an electrogenic and pH-independent manner. Translocates organic cations across the plasma membrane in both directions. Transports the polyamines spermine and spermidine. Transports pramipexole across the basolateral membrane of the proximal tubµLar epithelial cells. The choline transport is activated by MMTS. RegµLated by various intracellµLar signaling pathways including inhibition by protein kinase A activation, and endogenously activation by the calmodµLin complex, the calmodµLin-dependent kinase II and LCK tyrosine kinase. Clonality:Polyclonal Isotype:IgG Purification Method:>95%, Protein G purified Conjµgate:Biotin Buffer:Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 Form:Liquid Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Target Names:SLC22A1 Research Areas:Cancer; Metabolism; Signal transduction