ELISA SIAH2 Antibody, Biotin

Quantity :50µg Clone Number: Aliases:E3 ubiquitin-protein ligase Siah2 antibody; hSiah2 antibody; Seven in absentia homolog 2 antibody; Siah E3 ubiquitin protein ligase 2 antibody; Siah-2 antibody; siah2 antibody; SIAH2_ antibody; Ubiquitin Ligase Siah2 antibody Product Type:Polyclonal Antibody Immunogen Species:Homo sapiens () UniProt ID:O43255 Immunogen:Recombinant E3 ubiquitin-protein ligase SIAH2 protein (1-72AA) Raised in:Rabbit Reactivity: Tested Applications:ELISA Background:E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of target proteins. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjµgating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Mediates E3 ubiquitin ligase activity either throµgh direct binding to substrates or by functioning as the essential RING domain subunit of larger E3 complexes. Triggers the ubiquitin-mediated degradation of many substrates, including proteins involved in transcription regµLation (POU2AF1, PmL, NCOR1), a cell surface receptor (DCC), an antiapoptotic protein (BAG1), and a protein involved in synaptic vesicle function in neurons (SYP). Mediates ubiquitination and proteasomal degradation of DYRK2 in response to hypoxia. It is thereby involved in apoptosis, tumor suppression, cell cycle, transcription and signaling processes. Has some overlapping function with SIAH1. Triggers the ubiquitin-mediated degradation of TRAF2, whereas SIAH1 does not. Promotes monoubiquitination of SNCA. Clonality:Polyclonal Isotype:IgG Purification Method:>95%, Protein G purified Conjµgate:Biotin Buffer:Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 Form:Liquid Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Target Names:SIAH2 Research Areas:Neuroscience; Cancer; Cell biology