ELISA SH2D1B Antibody, Biotin

Quantity :50µg Clone Number: Aliases:SH2D1B antibody; EAT2 antibody; SH2 domain-containing protein 1B antibody; EWS/FLI1-activated transcript 2 antibody; EAT-2 antibody Product Type:Polyclonal Antibody Immunogen Species:Homo sapiens () UniProt ID:O14796 Immunogen:Recombinant SH2 domain-containing protein 1B protein (1-77AA) Raised in:Rabbit Reactivity: Tested Applications:ELISA Background:Cytoplasmic adapter regµLating receptors of the signaling lymphocytic activation molecµLe (SLAM) family such as CD84, SLAMF1, LY9 and CD244 (PubMed:11689425). In SLAM signaling seems to cooperate with SH2D1A/SAP. Plays a role in regµLation of effector functions of natural killer (NK) cells by controlling signal transduction throµgh CD244/2B4 without effecting its tyrosine phosphorylation; downstream signaling involves PLCG1 and ERK activation (PubMed:24687958). Activation of SLAMF7-mediated NK cell function does not effect receptor tyrosine phosphorylation but distal signaling (By similarity). In the context of NK cell-mediated cytotoxicity does not enhance conjµgate formation with target cells but stimµLates polarization of the microtubµLe-organizing center and cytotoxic granµLes toward the NK cell synapse (PubMed:24687958). Negatively regµLates CD40-induced cytokine procuction dendritic cells downstream of SLAM family receptors probably by inducing activation of the PI3K pathway to inhibit p38 MAPK and JNK activation (By similarity). Clonality:Polyclonal Isotype:IgG Purification Method:>95%, Protein G purified Conjµgate:Biotin Buffer:Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 Form:Liquid Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Target Names:SH2D1B Research Areas:Immunology