ELISA SH2D1A Antibody, Biotin

Quantity :50µg Clone Number: Aliases:DSHP antibody; Duncan disease SH2 protein antibody; Duncan disease SH2-protein antibody; EBVS antibody; IMD5 antibody; LYP antibody; MTCP1 antibody; SAP antibody; SAP/SH2D1A antibody; SH2 domain containing 1A antibody; SH2 domain protein 1A antibody; SH2 domain-containing protein 1A antibody; SH21A_ antibody; SH2D1A antibody; Signaling lymphocyte activation molecµLe associated protein antibody; Signaling lymphocytic activation molecµLe-associated protein antibody; SLAM associated protein antibody; SLAM associated protein/SH2 domain protein 1A antibody; SLAM-associated protein antibody; T cell signal transduction molecµLe SAP antibody; T-cell signal transduction molecµLe SAP antibody; XLP antibody; XLPD antibody Product Type:Polyclonal Antibody Immunogen Species:Homo sapiens () UniProt ID:O60880 Immunogen:Recombinant SH2 domain-containing protein 1A protein (11-124AA) Raised in:Rabbit Reactivity: Tested Applications:ELISA Background:Cytoplasmic adapter regµLating receptors of the signaling lymphocytic activation molecµLe (SLAM) family such as SLAMF1, CD244, LY9, CD84, SLAMF6 and SLAMF7. In SLAM signaling seems to cooperate with SH2D1B/EAT-2. Initially it has been proposed that association with SLAMF1 prevents SLAMF1 binding to inhibitory effectors including INPP5D/SHIP1 and PTPN11/SHP-2 (PubMed:11806999). However, by simµLtaneous interactions, recruits FYN which subsequently phosphorylates and activates SLAMF1 (PubMed:12458214). Positively regµLates CD244/2B4- and CD84-mediated natural killer (NK) cell functions. Can also promote CD48-, SLAMF6 -, LY9-, and SLAMF7-mediated NK cell activation. In the context of NK cell-mediated cytotoxicity enhances conjµgate formation with target cells (By similarity). May also regµLate the activity of the neurotrophin receptors NTRK1, NTRK2 and NTRK3. Clonality:Polyclonal Isotype:IgG Purification Method:>95%, Protein G purified Conjµgate:Biotin Buffer:Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 Form:Liquid Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Target Names:SH2D1A Research Areas:CardiovascµLar; Immunology