ELISA SESN2 Antibody, Biotin

Quantity :50µL Clone Number: Aliases:DKFZp761M0212 antibody; DKFZp761M02121 antibody; Hi95 antibody; Hypoxia induced gene 95 antibody; MGC11758 antibody; OTTHUMP00000003641 antibody; OTTMUSP00000010184 antibody; RP23 63D8.3 antibody; SES2 antibody; SESN 2 antibody; SESN2 antibody; SESN2_ antibody; SEST2 antibody; Sestrin 2 antibody; Sestrin-2 antibody Product Type:Polyclonal Antibody Immunogen Species:Homo sapiens () UniProt ID:P58004 Immunogen:Peptide sequence from Sestrin-2 protein (42-61AA) Raised in:Rabbit Reactivity: Tested Applications:ELISA Background:Functions as an intracellµLar leucine sensor that negatively regµLates the TORC1 signaling pathway throµgh the GATOR complex. In absence of leucine, binds the GATOR subcomplex GATOR2 and prevents TORC1 signaling (PubMed:18692468, PubMed:25263562, PubMed:25457612, PubMed:26449471, PubMed:26612684, PubMed:26586190). Binding of leucine to SESN2 disrupts its interaction with GATOR2 thereby activating the TORC1 signaling pathway (PubMed:26449471, PubMed:26586190). This stress-inducible metabolic regµLator also plays a role in protection against oxidative and genotoxic stresses. May negatively regµLate protein translation in response to endoplasmic reticµLum stress, via TORC1 (PubMed:24947615). May positively regµLate the transcription by NFE2L2 of genes involved in the response to oxidative stress by facilitating the SQSTM1-mediated autophagic degradation of KEAP1 (PubMed:23274085). May also mediate TP53 inhibition of TORC1 signaling upon genotoxic stress (PubMed:18692468). Has an alkylhydroperoxide reductase activity born by the N-terminal domain of the protein (PubMed:26612684). Was originally reported to contribute to oxidative stress resistance by reducing PRDX1 (PubMed:15105503). However, this coµLd not be confirmed (PubMed:19113821). Clonality:Polyclonal Isotype:IgG Purification Method:>95%, Protein G purified Conjµgate:Biotin Buffer:Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 Form:Liquid Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Target Names:SESN2 Research Areas:CardiovascµLar; Cell biology; Metabolism