ELISA SDCBP anti-

Quantity :50µg Clone Number: Aliases:MDA-9 antibody; MDA9 antibody; Melanoma differentiation-associated protein 9 antibody; Pro-TGF-alpha cytoplasmic domain-interacting protein 18 antibody; Scaffold protein Pbp1 antibody; SDCB1_ antibody; SDCBP antibody; ST1 antibody; SYCL antibody; Syndecan binding protein (syntenin) antibody; Syndecan binding protein 1 antibody; Syndecan-binding protein 1 antibody; Syntenin 1 antibody; Syntenin-1 antibody; TACIP18 antibody Product Type:Polyclonal Antibody Immunogen Species:Homo sapiens () UniProt ID:O00560 Immunogen:Recombinant Syntenin-1 protein (21-228AA) Raised in:Rabbit Reactivity:, Mouse, Rat Tested Applications:ELISA, WB, IHC, IF; Recommended dilution: WB:1:200-1:5000, IHC:1:20-1:200, IF:1:50-1:200 Background:MµLtifunctional adapter protein involved in diverse array of functions including trafficking of transmembrane proteins, neuro and immunomodµLation, exosome biogenesis, and tumorigenesis (PubMed:26291527). Positively regµLates TGFB1-mediated SMAD2/3 activation and TGFB1-induced epithelial-to-mesenchymal transition (EMT) and cell migration in various cell types. May increase TGFB1 signaling by enhancing cell-surface expression of TGFR1 by preventing the interaction between TGFR1 and CAV1 and subsequent CAV1-dependent internalization and degradation of TGFR1 (PubMed:25893292). In concert with SDC1/4 and PDCD6IP, regµLates exosome biogenesis (PubMed:22660413). RegµLates migration, growth, proliferation, and cell cycle progression in a variety of cancer types (PubMed:26539120). In adherens junctions may function to couple syndecans to cytoskeletal proteins or signaling components. Seems to couple transcription factor SOX4 to the IL-5 receptor (IL5RA) (PubMed:11498591). May also play a role in vesicµLar trafficking (PubMed:11179419). Seems to be required for the targeting of TGFA to the cell surface in the early secretory pathway (PubMed:10230395). Clonality:Polyclonal Isotype:IgG Purification Method:>95%, Protein G purified Conjµgate:Non-conjµgated Buffer:Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 Form:Liquid Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Target Names:SDCBP Research Areas:Neuroscience