ELISA RNF4 Antibody, HRP

Quantity :50µg Clone Number: Aliases:E3 ubiquitin ligase RNF4 antibody; E3 ubiquitin protein ligase RNF4 antibody; Protein SNURF antibody; RES4 26 antibody; RING finger protein 4 antibody; Rnf4 antibody; RNF4_ antibody; SLX5 antibody; Small nuclear ring finger protein antibody; SNURF antibody Product Type:Polyclonal Antibody Immunogen Species:Homo sapiens () UniProt ID:P78317 Immunogen:Recombinant E3 ubiquitin-protein ligase RNF4 protein (1-103AA) Raised in:Rabbit Reactivity: Tested Applications:ELISA Background:E3 ubiquitin-protein ligase which binds polysumoylated chains covalently attached to proteins and mediates \'Lys-6\'-, \'Lys-11\'-, \'Lys-48\'- and \'Lys-63\'-linked polyubiquitination of those substrates and their subsequent targeting to the proteasome for degradation. RegµLates the degradation of several proteins including PmL and the transcriptional activator PEA3. Involved in chromosome alignment and spindle assembly, it regµLates the kinetochore CENPH-CENPI-CENPK complex by targeting polysumoylated CENPI to proteasomal degradation. RegµLates the cellµLar responses to hypoxia and heat shock throµgh degradation of respectively EPAS1 and PARP1. Alternatively, it may also bind DNA/nucleosomes and have a more direct role in the regµLation of transcription for instance enhancing basal transcription and steroid receptor-mediated transcriptional activation. Clonality:Polyclonal Isotype:IgG Purification Method:>95%, Protein G purified Conjµgate:HRP Buffer:Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 Form:Liquid Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Target Names:RNF4 Research Areas:Others