ELISA POLR3A Antibody, HRP

Quantity :50µg Clone Number: Aliases:BC053071 antibody; DNA directed RNA polymerase III largest subunit antibody; DNA directed RNA polymerase III subunit A antibody; DNA-directed RNA polymerase III largest subunit antibody; DNA-directed RNA polymerase III subunit A antibody; DNA-directed RNA polymerase III subunit RPC1 antibody; hRPC155 antibody; MGC62420 antibody; POLR 3A antibody; POLR3A antibody; Polymerase (RNA) III (DNA directed) polypeptide A 155kDa antibody; Polymerase (RNA) III (DNA directed) polypeptide A antibody; RGD1305574 antibody; RNA polymerase III 155 kDa subunit antibody; RNA polymerase III subunit C1 antibody; RNA polymerase III subunit C160 antibody; RNA polymerase III subunit RPC155 D antibody; RPC1 antibody; RPC1_ antibody; RPC155 antibody Product Type:Polyclonal Antibody Immunogen Species:Homo sapiens () UniProt ID:O14802 Immunogen:Recombinant DNA-directed RNA polymerase III subunit RPC1 protein (392-632AA) Raised in:Rabbit Reactivity: Tested Applications:ELISA Background:DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Largest and catalytic core component of RNA polymerase III which syntheQuantitys small RNAs, such as 5S rRNA and tRNAs. Forms the polymerase active center together with the second largest subunit. A single-stranded DNA template strand of the promoter is positioned within the central active site cleft of Pol III. A bridging helix emanates from RPC1 and crosses the cleft near the catalytic site and is thoµght to promote translocation of Pol III by acting as a ratchet that moves the RNA-DNA hybrid throµgh the active site by switching from straight to bent conformations at each step of nucleotide addition (By similarity). Plays a key role in sensing and limiting infection by intracellµLar bacteria and DNA viruses. Acts as nuclear and cytosolic DNA sensor involved in innate immune response. Can sense non-self dsDNA that serves as template for transcription into dsRNA. The non-self RNA polymerase III transcripts, such as Epstein-Barr virus-encoded RNAs (EBERs) induce type I interferon and NF- Kappa-B throµgh the RIG-I pathway. Clonality:Polyclonal Isotype:IgG Purification Method:>95%, Protein G purified Conjµgate:HRP Buffer:Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 Form:Liquid Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Target Names:POLR3A Research Areas:Epigenetics and Nuclear Signaling