ELISA UVSSA Antibody, HRP

Quantity :50µg Clone Number: Aliases:hypothetical protein LOC57654 antibody; K1530_ antibody; KIAA1530 antibody; Uncharacterized protein KIAA1530 antibody; UV stimµLated scaffold protein A antibody; UVSS3 antibody; UVSSA antibody Product Type:Polyclonal Antibody Immunogen Species:Homo sapiens () UniProt ID:Q2YD98 Immunogen:Recombinant UV-stimµLated scaffold protein A protein (143-206AA) Raised in:Rabbit Reactivity: Tested Applications:ELISA Background:Factor involved in transcription-coupled nucleotide excision repair (TC-NER) in response to UV damage. TC-NER allows RNA polymerase II-blocking lesions to be rapidly removed from the transcribed strand of active genes. Acts by promoting stabilization of ERCC6 by recruiting deubiquitinating enzyme USP7 to TC-NER complexes, preventing UV-induced degradation of ERCC6 by the proteasome. Interacts with the elongating form of RNA polymerase II (RNA pol IIo) and facilitates its ubiquitination at UV damage sites, leading to promote RNA pol IIo backtracking to allow access to the nucleotide excision repair machinery. Not involved in processing oxidative damage. Clonality:Polyclonal Isotype:IgG Purification Method:>95%, Protein G purified Conjµgate:HRP Buffer:Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 Form:Liquid Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Target Names:UVSSA Research Areas: