ELISA ARF1 Antibody, Biotin

Quantity :50µg Clone Number: Aliases:ADP Ribosylation Factor 1 antibody; ADP-ribosylation factor 1 antibody; ARF 1 antibody; ARF1 antibody; ARF1_ antibody Product Type:Polyclonal Antibody Immunogen Species:Homo sapiens () UniProt ID:P84077 Immunogen:Recombinant ADP-ribosylation factor 1 protein (2-181AA) Raised in:Rabbit Reactivity: Tested Applications:ELISA Background:GTP-binding protein that functions as an allosteric activator of the cholera toxin catalytic subunit, an ADP-ribosyltransferase. Involved in protein trafficking among different compartments. ModµLates vesicle budding and uncoating within the Golgi complex. Deactivation induces the redistribution of the entire Golgi complex to the endoplasmic reticµLum, sµggesting a crucial role in protein trafficking. In its GTP-bound form, its triggers the association with coat proteins with the Golgi membrane. The hydrolysis of ARF1-bound GTP, which is mediated by ARFGAPs proteins, is required for dissociation of coat proteins from Golgi membranes and vesicles. The GTP-bound form interacts with PICK1 to limit PICK1-mediated inhibition of Arp2/3 complex activity; the function is linked to AMPA receptor (AMPAR) trafficking, regµLation of synaptic plasicity of excitatory synapses and spine shrinkage during long-term depression (LTD). Clonality:Polyclonal Isotype:IgG Purification Method:>95%, Protein G purified Conjµgate:Biotin Buffer:Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 Form:Liquid Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Target Names:ARF1 Research Areas:Signal transduction