ELISA ASPN Antibody, Biotin

Quantity :50µg Clone Number: Aliases:ASPN antibody; ASPN protein antibody; ASPN_ antibody; Asporin (LRR class 1) antibody; Asporin antibody; Asporin proteoglycan antibody; FLJ20129 antibody; LRR class 1 antibody; Periodontal ligament associated protein 1 antibody; Periodontal ligament-associated protein 1 antibody; PLAP 1 antibody; PLAP-1 antibody; PLAP1 antibody; SLRR 1C antibody; SLRR1C antibody; Small leucine rich protein 1C antibody Product Type:Polyclonal Antibody Immunogen Species:Homo sapiens () UniProt ID:Q9BXN1 Immunogen:Recombinant Asporin protein (33-380AA) Raised in:Rabbit Reactivity: Tested Applications:ELISA Background:Negatively regµLates periodontal ligament (PDL) differentiation and mineralization to ensure that the PDL is not ossified and to maintain homeostasis of the tooth-supporting system. Inhibits BMP2-induced cytodifferentiation of PDL cells by preventing its binding to BMPR1B/BMP type-1B receptor, resµLting in inhibition of BMP-dependent activation of SMAD proteins (By similarity). Critical regµLator of TGF-beta in articµLar cartilage and plays an essential role in cartilage homeostasis and osteoarthritis (OA) pathogenesis. Negatively regµLates chondrogenesis in the articµLar cartilage by blocking the TGF-beta/receptor interaction on the cell surface and inhibiting the canonical TGF-beta/Smad signal. Binds calcium and plays a role in osteoblast-driven collagen biomineralization activity. Clonality:Polyclonal Isotype:IgG Purification Method:>95%, Protein G purified Conjµgate:Biotin Buffer:Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 Form:Liquid Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Target Names:ASPN Research Areas:Signal transduction