ELISA AIRE Antibody, Biotin

Quantity :50µg Clone Number: Aliases:AIRE antibody; AIRE_ antibody; AIRE1 antibody; APECED antibody; APECED protein antibody; APS1 antibody; APSI antibody; Autoimmune polyendocrinopathy candidiasis ectodermal dystrophy protein antibody; Autoimmune regµLator antibody; Autoimmune regµLator protein antibody; PGA1 antibody Product Type:Polyclonal Antibody Immunogen Species:Homo sapiens () UniProt ID:O43918 Immunogen:Recombinant Autoimmune regµLator protein (39-108AA) Raised in:Rabbit Reactivity: Tested Applications:ELISA Background:Transcriptional regµLator that binds to DNA as a dimer or as a tetramer, but not as a monomer. Binds to G-doublets in an A/T-rich environment; the preferred motif is a tandem repeat of 5\'-. ATTGGTTA-3\' combined with a 5\'-TTATTA-3\' box. Binds to nucleosomes (By similarity). Binds to chromatin and interacts selectively with histone H3 that is not methylated at \'Lys-4\', not phosphorylated at \'Thr-3\' and not methylated at \'Arg-2\'. Functions as a sensor of histone H3 modifications that are important for the epigenetic regµLation of gene expression. Functions as a transcriptional activator and promotes the expression of otherwise tissue-specific self-antigens in the thymus, which is important for self tolerance and the avoidance of autoimmune reactions. Clonality:Polyclonal Isotype:IgG Purification Method:>95%, Protein G purified Conjµgate:Biotin Buffer:Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 Form:Liquid Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Target Names:AIRE Research Areas:Epigenetics and Nuclear Signaling; Immunology