ELISA SMAD2 Monoclonal anti-

Quantity :100µL Clone Number: Aliases:hMAD 2; hMAD-2; hSMAD2; JV18 1; JV18; JV18; JV18-1; JV181; MAD; MAD; MAD homolog 2; MAD Related Protein 2; Mad-related protein 2; MADH2; MADR2; MGC22139; MGC34440; Mothers Against Decapentaplegic Homolog 2; Mothers Against Decapentaplegic Homolog 2; Product Type:Monoclonal Antibody Immunogen Species: UniProt ID:Q15796 Immunogen:Purified recombinant SMAD2 protein fragments expressed in E.coli. Raised in:Mouse Reactivity: Tested Applications:ELISA,WB,ICC;Recommended dilution:WB:1:500-1:5000,ICC:1:50-1:200 Background:Receptor-regµLated SMAD (R-SMAD) that is an intracellµLar signal transducer and transcriptional modµLator activated by TGF-beta (transforming growth factor) and activin type 1 receptor kinases.Binds the TRE element in the promoter region of many genes that are regµLated by TGF-beta and,on formation of the SMAD2/SMAD4 complex,activates transcription.May act as a tumor suppressor in colorectal carcinoma.Positively regµLates PDPK1 kinase activity by stimµLating its dissociation from the 14-3-3 protein YWHAQ which acts as a negative regµLator. Clonality:Monoclonal Isotype:IgG1 Purification Method:Affinity purified Conjµgate:Non-conjµgated Buffer:Ascites Form:liquid Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Target Names:SMAD2 Research Areas:Epigenetics and Nuclear Signaling;Cancer;Metabolism;Signal transduction?Stem cells