3diag - KAP - Tia Kit (Kappa Light Chains)

Kit for determination of kappa immunoglobin in serum on routine biochemical analyzers. The kit includes a reagent, a calibrator and a control. In multiple pathological conditions such as multiple myeloma, Waldenström's macroglobulinemia, AL amyloidosis, light chain deposition disease (LCDD) and generally in all monoclonal gammopathy, the observation of a disorder of the κ/λ ratio or an increase in the amount of LC can be used to detect or confirm most abnormalities immunoglobulins. Moreover, in a situation of overproduction, there is an increase in the concentration of free LCs present in the serum, and when the reabsorption capacity of the tubules is exceeded, monoclonal FLCs are also found in the urine (so-called Bence-Jones proteinuria). This situation is another indicator of monoclonal gammopathy. However, if renal impairment is present, intact immunoglobulins may also appear in the urine, and since the assays measure both bound and free LC, the use of assays specific for free light chains may be recommended. In both serum and urine, confirmation of monoclonality should always be performed by other tests, not only immunochemical, such as electrophoresis, immunoelectrophoresis, or immunofixation. Applications for commonly used biochemical analyzers available (Advia®, Alinity C, AU®, Atellica™, cobas® C, Optilite®, Mindray and others).