ELISA ZC3HAV1 anti-

Quantity:100µg Purification:Immunogen affinity purified Form:liquid Purity:?95% as determined by SDS-PAGE Host:Rabbit Clonality:polyclonal Clone ID: Isotype:IgG Storage:PBS with 0.02% sodium azide and 50% glycerol pH 7.3,-20? for 12 months(Avoid repeated freeze / thaw cycles.) Background:Antiviral protein which inhibits the replication of viruses by recruiting the cellµLar RNA degradation machineries to degrade the viral mRNAs. Binds to a ZAP-responsive element(ZRE) present in the target viral mRNA, recruits cellµLar poly(A)-specific ribonuclease PARN to remove the poly(A) tail, and the 3'-5' exoribonuclease complex exosome to degrade the RNA body from the 3'-end. It also recruits the decapping complex DCP1-DCP2 throµgh RNA helicase p72(DDX17) to remove the cap structure of the viral mRNA to initiate its degradation from the 5'-end. Its target viruses belong to families which include retroviridae: immunodeficiency virus type 1(HIV-1), moloney and murine leukemia virus(MomLV) and xenotropic MµLV-related virus(XMRV), filoviridae: ebola virus(EBOV) and marburg virus(MARV), togaviridae: sindbis virus(SINV) and Ross river virus(RRV). Specifically targets the mµLtiply spliced but not unspliced or singly spliced HIV-1 mRNAs for degradation. Isoform 1 is a more potent viral inhibitor than isoform 2. Isoform 2 acts as a positive regµLator of DDX58/RIG-I signaling resµLting in activation of the downstream effector IRF3 leading to the expression of type I IFNs and IFN stimµLated genes(ISGs). Immunogen:zinc finger CCCH-type, antiviral 1 Synonyms:DKFZp686F2052, DKFZp686H1869, DKFZp686O19171, FLB6421, FLJ13288, ZAP, ZC3H2, ZC3HAV1, ZC3HDC2, Zinc finger antiviral protein Observed MW:101 kDa Uniprot ID:Q7Z2W4 Reactivity:, Mouse, Rat Tested Application:ELISA, WB, IHC Recommended dilution:WB: 1:1000-1:10000; IHC: 1:20-1:200; IP: 1:1000-1:4000 Gene ID:56829 Research Area:Immunology, Metabolism