ELISA FZD1 anti-

Quantity :50µg Clone Number: Aliases:Chfz-1 antibody; Dfrizzled-1 antibody; DKFZp564G072 antibody; FLJ95923 antibody; Frizzled 1 antibody; Frizzled homolog 1 (Drosophila) antibody; Frizzled homolog 1 antibody; Frizzled-1 antibody; Fz receptor 1 antibody; Fz-1 antibody; Fz1 antibody; FZD1 antibody; FZD1_ antibody; FzE1 antibody; hFz1 antibody; Rfz1 antibody; Wnt receptor antibody; Xfrizzled-1 antibody Product Type:Polyclonal Antibody Immunogen Species:Homo sapiens () UniProt ID:Q9UP38 Immunogen:Recombinant Frizzled-1 protein (73-322AA) Raised in:Rabbit Reactivity: Tested Applications:ELISA, IHC, IF; Recommended dilution: IHC:1:20-1:200, IF:1:50-1:200 Background:Receptor for Wnt proteins. Most of frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumµLation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. May be involved in transduction and intercellµLar transmission of polarity information during tissue morphogenesis and/or in differentiated tissues. Activated by Wnt3A, Wnt3, Wnt1 and to a lesser extent Wnt2, but not by Wnt4, Wnt5A, Wnt5B, Wnt6, Wnt7A or Wnt7B. Clonality:Polyclonal Isotype:IgG Purification Method:>95%, Protein G purified Conjµgate:Non-conjµgated Buffer:Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 Form:Liquid Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Target Names:FZD1 Research Areas:Cancer; Signal transduction; Stem cells