ELISA BAZ2A Antibody, HRP

Quantity :50µg Clone Number: Aliases:BAZ2A antibody; KIAA0314 antibody; TIP5Bromodomain adjacent to zinc finger domain protein 2A antibody; Transcription termination factor I-interacting protein 5 antibody; TTF-I-interacting protein 5 antibody; Tip5 antibody; hWALp3 antibody Product Type:Polyclonal Antibody Immunogen Species:Homo sapiens () UniProt ID:Q9UIF9 Immunogen:Recombinant Bromodomain adjacent to zinc finger domain protein 2A protein (97-266AA) Raised in:Rabbit Reactivity: Tested Applications:ELISA Background:Essential component of the NoRC (nucleolar remodeling complex) complex, a complex that mediates silencing of a fraction of rDNA by recruiting histone-modifying enzymes and DNA methyltransferases, leading to heterochromatin formation and transcriptional silencing. In the complex, it plays a central role by being recruited to rDNA and by targeting chromatin modifying enzymes such as HDAC1, leading to repress RNA polymerase I transcription. Recruited to rDNA via its interaction with TTF1 and its ability to recognize and bind histone H4 acetylated on \\\'Lys-16\\\' (H4K16ac), leading to deacetylation of H4K5ac, H4K8ac, H4K12ac but not H4K16ac. Specifically binds pRNAs, 150-250 nucleotide RNAs that are complementary in sequence to the rDNA promoter; pRNA-binding is required for heterochromatin formation and rDNA silencing (By similarity). Clonality:Polyclonal Isotype:IgG Purification Method:>95%, Protein G purified Conjµgate:HRP Buffer:Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 Form:Liquid Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Target Names:BAZ2A Research Areas:Others