ELISA PSENEN Antibody, Biotin

Quantity :50µL Clone Number: Aliases:Gamma secretase subunit PEN 2 antibody; Gamma Secretase Subunit PEN2 antibody; Gamma-secretase subunit PEN-2 antibody; Hematopoietic stem/progenitor cells protein MDS033 antibody; MDS033 antibody; MSTP064 antibody; PEN 2 antibody; PEN2_ antibody; Presenilin Enhancer 2 antibody; Presenilin enhancer 2 homolog antibody; Presenilin enhancer protein 2 antibody; PSEN2 antibody; psenen antibody Product Type:Polyclonal Antibody Immunogen Species:Homo sapiens () UniProt ID:Q9NZ42 Immunogen:Peptide sequence from Gamma-secretase subunit PEN-2 protein (39-57AA) Raised in:Rabbit Reactivity: Tested Applications:ELISA Background:Essential subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (beta-amyloid precursor protein) (PubMed:12522139, PubMed:12763021, PubMed:12740439, PubMed:12679784, PubMed:24941111). The gamma-secretase complex plays a role in Notch and Wnt signaling cascades and regµLation of downstream processes via its role in processing key regµLatory proteins, and by regµLating cytosolic CTNNB1 levels (Probable). PSENEN modµLates both endoproteolysis of presenilin and gamma-secretase activity (PubMed:12522139, PubMed:12763021, PubMed:12740439, PubMed:12679784, PubMed:24941111). Clonality:Polyclonal Isotype:IgG Purification Method:>95%, Protein G purified Conjµgate:Biotin Buffer:Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 Form:Liquid Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Target Names:PSENEN Research Areas:Neuroscience