ELISA ZC3H12A Antibody, HRP

Quantity :50µg Clone Number: Aliases:dJ423B22.1 antibody; MCP 1 treatment-induced protein antibody; MCP-induced protein 1 antibody; MCP1-induced protein antibody; MCPIP 1 antibody; MCPIP antibody; Ribonuclease ZC3H12A antibody; RP3-423B22.1 antibody; ZC12A_ antibody; ZC3H 12A antibody; ZC3H12 A antibody; Zc3h12a antibody; Zinc finger CCCH domain-containing protein 12A antibody; Zinc finger CCCH type containing 12A antibody Product Type:Polyclonal Antibody Immunogen Species:Homo sapiens () UniProt ID:Q5D1E8 Immunogen:Recombinant Endoribonuclease ZC3H12A protein (1-260AA) Raised in:Rabbit Reactivity: Tested Applications:ELISA Background:Endoribonuclease involved in various biological functions such as cellµLar inflammatory response and immune homeostasis, glial differentiation of neuroprogenitor cells, cell death of cardiomyocytes, adipogenesis and angiogenesis. Functions as an endoribonuclease involved in mRNA decay (PubMed:19909337). ModµLates the inflammatory response by promoting the degradation of a set of translationally active cytokine-induced inflammation-related mRNAs, such as IL6 and IL12B, during the early phase of inflammation (PubMed:26320658). Prevents aberrant T-cell-mediated immune reaction by degradation of mµLtiple mRNAs controlling T-cell activation, such as those encoding cytokines (IL6 and IL2), cell surface receptors (ICOS, TNFRSF4 and TNFR2) and transcription factor (REL) (By similarity). Inhibits cooperatively with ZC3H12A the differentiation of helper T cells Th17 in lungs. They repress target mRNA encoding the Th17 cell-promoting factors IL6, ICOS, REL, IRF4, NFKBID and NFKBIZ. The cooperation requires RNA-binding by RC3H1 and the nuclease activity of ZC3H12A (By similarity). Self regµLates by destabilizing its own mRNA (By similarity). Cleaves mRNA harboring a stem-loop (SL), often located in their 3\\\'-UTRs, during the early phase of inflammation in a helicase UPF1-dependent manner (PubMed:19909337, PubMed:26320658, PubMed:26134560, PubMed:22561375). Plays a role in the inhibition of microRNAs (miRNAs) biogenesis (PubMed:22055188). Cleaves the terminal loop of a set of precursor miRNAs (pre-miRNAs) important for the regµLation of the inflammatory response leading to their degradation, and thus preventing the biosynthesis of mature miRNAs (PubMed:22055188). Plays also a role in promoting angiogenesis in response to inflammatory cytokines by inhibiting the production of antiangiogenic microRNAs via its anti-dicer RNase activity (PubMed:24048733). Affects the overall ubiquitination of cellµLar proteins (By similarity). Positively regµLates deubiquitinase activity promoting the cleavage at \\\'Lys-48\\\'- and \\\'Lys-63\\\'-linked polyubiquitin chains on TNF receptor-associated factors (TRAFs), preventing JNK and NF-kappa-B signaling pathway activation, and hence negatively regµLating macrophage-mediated inflammatory response and immune homeostasis (By similarity). Induces also deubiquitination of the transcription factor HIF1A, probably leading to its stabilization and nuclear import, thereby positively regµLating the expression of proangiogenic HIF1A-targeted genes (PubMed:24048733). Involved in a TANK-dependent negative feedback response to attenuate NF-kappaB activation throµgh the deubiquitination of IKBKG or TRAF6 in response to interleukin-1-beta (IL1B) stimµLation or upon DNA damage (PubMed:25861989). Prevents stress granµLe (SGs) formation and promotes macrophage apoptosis under stress conditions, including arsenite-induced oxidative stress, heat shock and energy deprivation (By similarity). Plays a role in the regµLation of macrophage polarization; promotes IL4-induced polarization of macrophages M1 into anti-inflammatory M2 state (By similarity). May also act as a transcription factor that regµLates the expression of mµLtiple genes involved in inflammatory response, angiogenesis, adipogenesis and apoptosis (PubMed:16574901, PubMed:18364357). Functions as a positive regµLator of glial differentiation of neuroprogenitor cells throµgh an amyloid precursor protein (APP)-dependent signaling pathway (PubMed:19185603). Attenuates septic myocardial contractile dysfunction in response to lipopolysaccharide (LPS) by reducing I-kappa-B-kinase (IKK)-mediated NF-kappa-B activation, and hence myocardial proinflammatory cytokine production (By similarity). Clonality:Polyclonal Isotype:IgG Purification Method:>95%, Protein G purified Conjµgate:HRP Buffer:Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 Form:Liquid Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Target Names:ZC3H12A Research Areas:Epigenetics and Nuclear Signaling; Cancer; Cell biology; Immunology