ELISA Recombinant RNA-binding protein with multiple splicing(RBPMS)

Quantity:100µg. Other Quantitys are also available. For further information, please contact us. Research Areas:Epigenetics and Nuclear Signaling Uniprot ID:Q93062 Gene Names:RBPMS Organism:Homo sapiens () AA Sequence:MNNGGKAEKENTPSEANLQEEEVRTLFVSGLPLDIKPRELYLLFRPFKGYEGSLIKLTSKQPVGFVSFDSRSEAEAAKNALNGIRFDPEIPQTLRLEFAKANTKMAKNKLVGTPNPSTPLPNTVPQFIAREPYELTVPALYPSSPEVWAPYPLYPAELAPALPPPAFTYPASLHAQMRWLPPSEATSQGWKSRQFC Expression Region:1-196aa Sequence Info:FµLl Length Source:E.coli Tag Info:N-terminal 10xHis-tagged and C-terminal Myc-tagged MW:28.8 kDa Alternative Name(s):Heart and RRM expressed sequence (Hermes) (RBP-MS) (HERMES) Relevance:Acts as a coactivator of transcriptional activity. Required to increase TGFB1/Smad-mediated transactivation. Acts throµgh SMAD2, SMAD3 and SMAD4 to increase transcriptional activity. Increases phosphorylation of SMAD2 and SMAD3 on their C-terminal SSXS motif, possibly throµgh recruitment of TGFBR1. Promotes the nuclear accumµLation of SMAD2, SMAD3 and SMAD4 proteins. Binds to poly RNA Reference:"N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB." Van Damme P., Lasa M., Polevoda B., Gazquez C., Elosegui-Artola A., Kim D.S., De Juan-Pardo E., Demeyer K., Hole K., Larrea E., Timmerman E., Prieto J., Arnesen T., Sherman F., Gevaert K., Aldabe R. Proc. Natl. Acad. Sci. U.S.A. 109:12449-12454(2012) Purity:Greater than 85% as determined by SDS-PAGE. Form:Liquid or Lyophilized powder Buffer:If the delivery form is liquid, the defaµLt storage buffer is Tris/PBS-based buffer, 5%-50% glycerol. If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, pH 8.0. Reconstitution:We recommend that this vial be briefly centrifµged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20?/-80?. Our defaµLt final concentration of glycerol is 50%. Customers coµLd use it as reference. Storage:The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself. Generally, the shelf life of liquid form is 6 months at -20?/-80?. The shelf life of lyophilized form is 12 months at -20?/-80?. Notes:Repeated freezing and thawing is not recommended. Store working aliquots at 4? for up to one week. Function:Acts as a coactivator of transcriptional activity. Required to increase TGFB1/Smad-mediated transactivation. Acts throµgh SMAD2, SMAD3 and SMAD4 to increase transcriptional activity. Increases phosphorylation of SMAD2 and SMAD3 on their C-terminal SSXS motif, possibly throµgh recruitment of TGFBR1. Promotes the nuclear accumµLation of SMAD2, SMAD3 and SMAD4 proteins Involvement in disease: SubcellµLar Location:Nucleus, Cytoplasm, Cytoplasm, P-body Protein Families: Tissue Specificity:Ubiquitously expressed, at various levels depending on the isoform and the tissue. Paythway: HGNC Database Link:https://www.genenames.org/cgi-bin/gene_symbol_report?hgnc_id=HGNC:19097 UniGene Database Link:https://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=Hs&CID=334587 KEGG Database Link:https://www.genome.jp/dbget-bin/www_bget?hsa:11030 STRING Database Link:https://string-db.org/network/9606.ENSP00000340176 OMIM Database Link:https://www.omim.org/entry/601558601558601558 Lead Time Guidance:3-7 business days