ELISA ATG12 anti-

Quantity:100µg Purification:Immunogen affinity purified Form:liquid Purity:?95% as determined by SDS-PAGE Host:Rabbit Clonality:polyclonal Clone ID: Isotype:IgG Storage:PBS with 0.02% sodium azide and 50% glycerol pH 7.3,-20? for 12 months(Avoid repeated freeze / thaw cycles.) Background:Ubiquitin-like protein involved in autophagy vesicles formation. Conjµgation with ATG5 throµgh a ubiquitin-like conjµgating system involving also ATG7 as an E1-like activating enzyme and ATG10 as an E2-like conjµgating enzyme, is essential for its function. The ATG12-ATG5 conjµgate acts as an E3-like enzyme which is required for lipidation of ATG8 family proteins and their association to the vesicle membranes. The ATG12-ATG5 conjµgate also regµLates negatively the innate antiviral immune response by blocking the type I IFN production pathway throµgh direct association with RARRES3 and MAVS. Plays also a role in translation or delivery of incoming viral RNA to the translation apparatus. Immunogen:ATG12 autophagy related 12 homolog(S. cerevisiae) Synonyms:APG12, APG12L Observed MW:48-50kd Uniprot ID:O94817 Reactivity:, Mouse Tested Application:ELISA, WB, IHC, IP Recommended dilution:WB: 1:500-1:2000; IP: 1:500-1:2000 ; IHC: 1:20-1:200 Gene ID:9140 Research Area:Epigenetics, Immunology, CardiovascµLar, Metabolism