ELISA BIRC7 anti-

Quantity :50µL Clone Number: Aliases:BacµLoviral IAP repeat containing 7 antibody; BacµLoviral IAP repeat containing protein 7 antibody; BacµLoviral IAP repeat-containing protein 7 antibody; BIRC 7 antibody; birc7 antibody; BIRC7_ antibody; KIAP antibody; Kidney inhibitor of apoptosis protein antibody; Livin antibody; Livin inhibitor of apotosis antibody; Melanoma inhibitor of apoptosis protein antibody; mL IAP antibody; mL-IAP antibody; mLIAP antibody; RING finger protein 50 antibody; RNF 50 antibody; RNF50 antibody Product Type:Polyclonal Antibody Immunogen Species:Homo sapiens () UniProt ID:Q96CA5 Immunogen:Recombinant BacµLoviral IAP repeat-containing protein 7 protein (1-265AA) Raised in:Rabbit Reactivity: Tested Applications:ELISA, WB; Recommended dilution: WB:1:200-1:1000 Background:Apoptotic regµLator capable of exerting proapoptotic and anti-apoptotic activities and plays crucial roles in apoptosis, cell proliferation, and cell cycle control. Its anti-apoptotic activity is mediated throµgh the inhibition of CASP3, CASP7 and CASP9, as well as by its E3 ubiquitin-protein ligase activity. As it is a weak caspase inhibitor, its anti-apoptotic activity is thoµght to be due to its ability to ubiquitinate DIABLO/SMAC targeting it for degradation thereby promoting cell survival. May contribute to caspase inhibition, by blocking the ability of DIABLO/SMAC to disrupt XIAP/BIRC4-caspase interactions. Protects against apoptosis induced by TNF or by chemical agents such as adriamycin, etoposide or staurosporine. Suppression of apoptosis is mediated by activation of MAPK8/JNK1, and possibly also of MAPK9/JNK2. This activation depends on TAB1 and NR2C2/TAK1. In vitro, inhibits CASP3 and proteolytic activation of pro-CASP9. Isoform 1 blocks staurosporine-induced apoptosis. Isoform 2 blocks etoposide-induced apoptosis. Isoform 2 protects against natural killer (NK) cell killing whereas isoform 1 aµgments killing. Clonality:Polyclonal Isotype:IgG Purification Method:Antigen Affinity Purified Conjµgate:Non-conjµgated Buffer:PBS with 0.02% sodium azide, 50% glycerol, pH7.3. Form:Liquid Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Target Names:BIRC7 Research Areas:Cancer; Cell biology