ELISA APOBEC3F Antibody, Biotin

Quantity :50µg Clone Number: Aliases:A3F antibody; ABC3F_ antibody; APOBEC3F antibody; Apolipoprotein B mRNA editing enzyme; catalytic polypeptide like 3F antibody; Apolipoprotein B mRNA-editing enzyme catalytic polypeptide-like 3F antibody; ARP8 antibody; DNA dC->dU-editing enzyme APOBEC-3F antibody; Induced upon T cell activation antibody; KA6 antibody Product Type:Polyclonal Antibody Immunogen Species:Homo sapiens () UniProt ID:Q8IUX4 Immunogen:Recombinant DNA dC->dU-editing enzyme APOBEC-3F protein (139-287AA) Raised in:Rabbit Reactivity: Tested Applications:ELISA Background:DNA deaminase (cytidine deaminase) which acts as an inhibitor of retrovirus replication and retrotransposon mobility via deaminase-dependent and -independent mechanisms. Exhibits antiviral activity against vif-deficient HIV-1. After the penetration of retroviral nucleocapsids into target cells of infection and the initiation of reverse transcription, it can induce the conversion of cytosine to uracil in the minus-sense single-strand viral DNA, leading to G-to-A hypermutations in the subsequent plus-strand viral DNA. The resµLtant detrimental levels of mutations in the proviral genome, along with a deamination-independent mechanism that works prior to the proviral integration, together exert efficient antiretroviral effects in infected target cells. Selectively targets single-stranded DNA and does not deaminate double-stranded DNA or single- or double-stranded RNA. Exhibits antiviral activity also against hepatitis B virus (HBV), equine infectious anemia virus (EIAV), xenotropic MµLV-related virus (XMRV) and simian foamy virus (SFV) and may inhibit the mobility of LTR and non-LTR retrotransposons. May also play a role in the epigenetic regµLation of gene expression throµgh the process of active DNA demethylation. Clonality:Polyclonal Isotype:IgG Purification Method:>95%, Protein G purified Conjµgate:Biotin Buffer:Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 Form:Liquid Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Target Names:APOBEC3F Research Areas:Others