ELISA Phospho-EPOR (Tyr368) anti-

Quantity :100µL Clone Number: Aliases:EPO R antibody; EPO Receptor antibody; EPO-R antibody; epor antibody; EPOR_ antibody; Erythropoietin receptor antibody; Erythropoietin receptor precursor antibody; MGC138358 antibody Product Type:Polyclonal Antibody Immunogen Species:Homo sapiens () UniProt ID:P19235 Immunogen:Peptide sequence around phosphorylation site of Tyrosine 368 (D-T-Y(p)-L-V) derived from Epo-R. Raised in:Rabbit Reactivity:, Mouse, Rat Tested Applications:ELISA, WB; WB:1:500-1:1000 Background: Receptor for erythropoietin. Mediates erythropoietin-induced erythroblast proliferation and differentiation. Upon EPO stimµLation, EPOR dimerizes triggering the JAK2/STAT5 signaling cascade. In some cell types, can also activate STAT1 and STAT3. May also activate the LYN tyrosine kinase. Isoform EPOR-T acts as a dominant-negative receptor of EPOR-mediated signaling. Funakoshi-Tago M, et al. (2010) J Biol Chem 285, 5296-307 SµLahian R, Cleaver O, Huang LJ (2009) Blood 113, 5287-97 Zhang YL, et al. (2009) Mol Cell 33, 266-74 Clonality:Polyclonal Isotype:IgG Purification Method:Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjµgates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy usi Conjµgate:Non-conjµgated Buffer:Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Form:liquid Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Target Names:EPOR Research Areas:CardiovascµLar;Immunology;Signal transduction?Stem cells