ELISA WSS1 Antibody, Biotin

Quantity :50µg Clone Number: Aliases:WSS1 antibody; YHR134WDNA-dependent metalloprotease WSS1 antibody; EC 3.4.24.- antibody; DNA damage response protein WSS1 antibody; SUMO-dependent isopeptidase WSS1 antibody; Weak suppressor of SMT3 protein 1 antibody Product Type:Polyclonal Antibody Immunogen Species:Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) UniProt ID:P38838 Immunogen:Recombinant Saccharomyces cerevisiae DNA-dependent metalloprotease WSS1 protein (1-269AA) Raised in:Rabbit Reactivity:Saccharomyces cerevisiae Tested Applications:ELISA Background:Metalloendopeptidase that acts selectively on DNA-binding proteins. DNA is needed to bring the protease and substrates together to enable proteolysis. Involved in the repair of toxic DNA-protein cross-links (DPCs) such as covalently trapped topoisomerase 1 (TOP1) adducts on DNA lesions or DPCs induced by reactive compounds such as formaldehyde. Involved in DNA damage response and processing of stalled or collapsed replication forks by removing the covalently trapped TOP1 from chromatin. DPC proteolysis enables the repair of the lesions via downstream DNA repair pathways. May be recruited to DPCs via the SUMOylation of substrate proteins at damaged DNA sites. Clonality:Polyclonal Isotype:IgG Purification Method:>95%, Protein G purified Conjµgate:Biotin Buffer:Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 Form:Liquid Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Target Names:WSS1 Research Areas:Others