ELISA ZFYVE19 anti-

Quantity :100µL Clone Number: Aliases:Abscission/NoCut checkpoint regµLator antibody; ANCHR antibody; mLL partner containing FYVE domain antibody; MPFYVE antibody; ZFY19_ antibody; ZFYVE 19 antibody; Zfyve19 antibody; Zinc finger FYVE domain containing protein 19 antibody; Zinc finger FYVE domain-containing protein 19 antibody; Zinc finger FYVE type containing 19 antibody; Zinc finger; FYVE domain containing 19 antibody Product Type:Polyclonal Antibody Immunogen Species:Homo sapiens () UniProt ID:Q96K21 Immunogen:SyntheQuantityd peptide derived from internal of ZFYVE19. Raised in:Rabbit Reactivity: Tested Applications:ELISA, WB, IHC; WB:1:500-1:3000, IHC:1:50-1:100 Background:Key regµLator of abscission step in cytokinesis: part of the cytokinesis checkpoint, a process required to delay abscission to prevent both premature resolution of intercellµLar chromosome bridges and accumµLation of DNA damage. Together with CHMP4C, required to retain abscission-competent VPS4 (VPS4A and/or VPS4B) at the midbody ring until abscission checkpoint signaling is terminated at late cytokinesis. Deactivation of AURKB resµLts in dephosphorylation of CHMP4C followed by its dissociation from ZFYVE19/ANCHR and VPS4 and subsequent abscission. Chinwalla V., Oncogene 22:1400-1410(2003). Ota T., Nat. Genet. 36:40-45(2004). The MGC Project Team, Genome Res. 14:2121-2127(2004). Clonality:Polyclonal Isotype:IgG Purification Method:The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. Conjµgate:Non-conjµgated Buffer:Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Form:liquid Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Target Names:ZFYVE19 Research Areas:Cell biology