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ELISA XRCC6 anti-

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Quantity :100µL Clone Number: Aliases:5''-deoxyribose-5-phosphate lyase Ku70 antibody; 5''-dRP lyase Ku70 antibody; 70 kDa subunit of Ku antigen antibody; ATP dependent DNA helicase 2 subunit 1 antibody; ATP dependent DNA helicase II 70 kDa subunit antibody; ATP-dependent DNA helicase 2 subunit 1 antibody; ATP-dependent DNA helicase II 70 kDa subunit antibody; CTC box binding factor 75 kDa subunit antibody; CTC box-binding factor 75 kDa subunit antibody; CTC75 antibody; CTCBF antibody; DNA repair protein XRCC6 antibody; G22P1 antibody; Ku 70 antibody; Ku autoantigen p70 subunit antibody; Ku autoantigen, 70kDa antibody; Ku p70 antibody; Ku70 antibody; Ku70 DNA binding component of DNA-dependent proteinkinase complex (thyroid autoantigen 70 kDa antibody; Kup70 antibody; Lupus Ku autoantigen protein p70 antibody; mL8 antibody; Thyroid autoantigen 70kD (Ku antigen) antibody; Thyroid autoantigen antibody; Thyroid lupus autoantigen antibody; Thyroid lupus autoantigen p70 antibody; Thyroid-lupus autoantigen antibody; TLAA antibody; X ray repair complementing defective repair in Chinese hamster cells 6 antibody; X-ray repair complementing defective repair in Chinese hamster cells 6 antibody; X-ray repair cross-complementing protein 6 antibody; XRCC 6 antibody; Xrcc6 antibody; XRCC6_ antibody Product Type:Polyclonal Antibody Immunogen Species:Homo sapiens () UniProt ID:P12956 Immunogen:SyntheQuantityd peptide derived from C-terminal of XRCC6. Raised in:Rabbit Reactivity:, Mouse Tested Applications:ELISA, WB, IHC; WB:1:500-1:3000, IHC:1:50-1:100 Background:Single-stranded DNA-dependent ATP-dependent helicase. Has a role in chromosome translocation. The DNA helicase II complex binds preferentially to fork-like ends of double-stranded DNA in a cell cycle-dependent manner. It works in the 3'-5' direction. Binding to DNA may be mediated by XRCC6. Involved in DNA non-homologous end joining (NHEJ) required for double-strand break repair and V(D)J recombination. The XRCC5/6 dimer acts as regµLatory subunit of the DNA-dependent protein kinase complex DNA-PK by increasing the affinity of the catalytic subunit PRKDC to DNA by 100-fold. The XRCC5/6 dimer is probably involved in stabilizing broken DNA ends and bringing them together. The assembly of the DNA-PK complex to DNA ends is required for the NHEJ ligation step. Required for osteocalcin gene expression. Probably also acts as a 5'-deoxyribose-5-phosphate lyase (5'-dRP lyase), by catalyzing the beta-elimination of the 5' deoxyribose-5-phosphate at an abasic site near double-strand breaks. 5'-dRP lyase activity allows to 'clean' the termini of abasic sites, a class of nucleotide damage commonly associated with strand breaks, before such broken ends can be joined. The XRCC5/6 dimer together with APEX1 acts as a negative regµLator of transcription. Yanhong Liu, Carcinogenesis, Mar 2007; 10.1093. Erich M. Sturgis, Arch Otolaryngol Head Neck Surg, Feb 1999; 125: 185. Yansong Gu, PNAS, JµL 1997; 94: 8076. Kyoung-Mu Lee, Clin. Cancer Res., Jun 2005; 11: 4620 - 4626. Clonality:Polyclonal Isotype:IgG Purification Method:The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. Conjµgate:Non-conjµgated Buffer:Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Form:liquid Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Target Names:XRCC6 Research Areas:Epigenetics and Nuclear Signaling;Cancer

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