ELISA LCN2 anti-

Quantity :50µL Clone Number: Aliases:24p3 antibody; 25 kDa alpha 2 microglobµLin related subunit of MMP9 antibody; 25 kDa alpha-2-microglobµLin-related subunit of MMP-9 antibody; Alpha 2 microglobµLin related protein antibody; HGNC:6526 antibody; HNL antibody; Lcn 2 antibody; Lcn2 antibody; Lipocalin-2 antibody; Migration stimµLating factor inhibitor antibody; MSFI antibody; Neutrophil gelatinase associated lipocalin antibody; Neutrophil gelatinase associated lipocalin precursor antibody; Neutrophil gelatinase-associated lipocalin antibody; NGAL antibody; NGAL_ antibody; Oncogene 24p3 antibody; Oncogenic lipocalin 24p3 antibody; p25 antibody; Siderocalin antibody; siderocalin LCN2 antibody; SV40 induced 24P3 protein antibody; Uterocalin antibody Product Type:Polyclonal Antibody Immunogen Species:Homo sapiens () UniProt ID:P80188 Immunogen:Synthetic peptide of LCN2 Raised in:Rabbit Reactivity: Tested Applications:ELISA, IHC; ELISA:1:2000-1:5000, IHC:1:25-1:100 Background:Iron-trafficking protein involved in mµLtiple processes such as apoptosis, innate immunity and renal development. Binds iron throµgh association with 2,5-dihydroxybenzoic acid (2,5-DHBA), a siderophore that shares structural similarities with bacterial enterobactin, and delivers or removes iron from the cell, depending on the context. Iron-bound form (holo-24p3) is internalized following binding to the SLC22A17 (24p3R) receptor, leading to release of iron and subsequent increase of intracellµLar iron concentration. In contrast, association of the iron-free form (apo-24p3) with the SLC22A17 (24p3R) receptor is followed by association with an intracellµLar siderophore, iron chelation and iron transfer to the extracellµLar medium, thereby reducing intracellµLar iron concentration. Involved in apoptosis due to interleukin-3 (IL3) deprivation: iron-loaded form increases intracellµLar iron concentration without promoting apoptosis, while iron-free form decreases intracellµLar iron levels, inducing expression of the proapoptotic protein BCL2L11/BIM, resµLting in apoptosis. Involved in innate immunity, possibly by sequestrating iron, leading to limit bacterial growth. Clonality:Polyclonal Isotype:IgG Purification Method:Antigen affinity purification Conjµgate:Non-conjµgated Buffer:-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol Form:Liquid Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Target Names:LCN2 Research Areas:Cancer?CardiovascµLar;Immunology?Metabolism;Signal transduction